Towards Quantitative Simulations of High Power Proton Cyclotrons

PSI operates a cyclotron based high intensity proton accelerator routinely at an average beam power of 1.3MW. With this power the facility is at the worldwide forefront of high intensity proton accelerators. The beam current is practically limited by losses at extraction and the resulting activation of accelerator components. Further intensity upgrades and new projects aiming at an even higher average beam power, are only possible if the relative losses can be lowered in proportion, thus keeping absolute losses at a constant level. Maintaining beam losses at levels allowing hands-on maintenance is a primary challenge in any high power proton machine design and operation. In consequence, predicting beam halo at these levels is a great challenge and will be addressed in this paper. High power hadron driver have being used in many disciplines of science and, a growing interest in the cyclotron technology for high power hadron drivers are being observed very recently. This report will briefly introduce OPAL, a tool for precise beam dynamics simulations including 3D space charge. One of OPAL's flavors (OPAL-cycl) is dedicated to high power cyclotron modeling and is explained in greater detail. We then explain how to obtain initial conditions for our PSI Ring cyclotron which still delivers the world record in beam power of 1.3 MW continuous wave (cw). Several crucial steps are explained necessary to be able to predict tails at the level of 3\sigma ... 4\sigma in the PSI Ring cyclotron. We compare our results at the extraction with measurements, obtained with a 1.18 MW cw production beam. Based on measurement data, we develop a simple linear model to predict beam sizes of the extracted beam as a function of intensities and confirm the model with simulations.Comment: Corrections and new figur

Beam Dynamics in High Intensity Cyclotrons Including Neighboring Bunch Effects: Model, Implementation and Application

Space charge effects, being one of the most significant collective effects, play an important role in high intensity cyclotrons. However, for cyclotrons with small turn separation, other existing effects are of equal importance. Interactions of radially neighboring bunches are also present, but their combined effects has not yet been investigated in any great detail. In this paper, a new particle in cell based self-consistent numerical simulation model is presented for the first time. The model covers neighboring bunch effects and is implemented in the three-dimensional object-oriented parallel code OPAL-cycl, a flavor of the OPAL framework. We discuss this model together with its implementation and validation. Simulation results are presented from the PSI 590 MeV Ring Cyclotron in the context of the ongoing high intensity upgrade program, which aims to provide a beam power of 1.8 MW (CW) at the target destination

Chin cup therapy for mandibular prognathism

The purpose of this work was to provide a comprehensive description of craniofacial alteration in the Class III patient in response to orthopedic chin cup treatment. Thirty patients with skeletal Class III malocclusion under treatment with the chin cup appliance, averaging 6 years of age at the start of treatment, were followed longitudinally for a 3-year period. This treatment sample was compared cephalometrically with an analogous untreated Class III sample.The following significant craniofacial alterations were noted in the sample that underwent orthopedic chin cup therapy: 1. 1. A retardation of vertical ramus growth.2. 2. A retardation of vertical development in the posterior aspect of the mandibular body.3. 3. A retardation of vertical development in the posterior maxilla.4. 4. A closure of the gonial angle.5. 5. A distal rotation of the mandibular complex.6. 6. A decreased amount of anteroposterior anterior cranial base growth.7. 7. A redirection of the predominantly horizontal mandibular growth pattern to a more vertical direction.8. 8. A reduction of the maxillomandibular malrelationship toward normative values.9. 9. A production of an Angle Class I dental relationship following the establishment of normal maxillomandibular relations.10. 10. A lack of detectable localized effect on the symphyseal region or incisor position as a direct result of chin cup placement and pressure.11. 11. Development of soft-tissue profile changes in harmony with underlying skeletal changes.While all of the listed alterations are important when analyzed separately, they gain increased importance when considered together. With orthopedic chin cup therapy, there is a change in craniofacial pattern leading to the observed resolution of the Angle skeletal Class III malocclusion. This study thus provides strong support for the use of the orthopedic-force chin cup appliance in the clinical management of young patients with skeletal mandibular prognathism.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23012/1/0000581.pd

High Resistance of Plasmodium falciparum to Sulphadoxine/Pyrimethamine in Northern Tanzania and the Emergence of dhps Resistance Mutation at Codon 581

BACKGROUND: Sulphadoxine-pyrimethamine (SP) a widely used treatment for uncomplicated malaria and recommended for intermittent preventive treatment of malaria in pregnancy, is being investigated for intermittent preventive treatment of malaria in infants (IPTi). High levels of drug resistance to SP have been reported from north-eastern Tanzania associated with mutations in parasite genes. This study compared the in vivo efficacy of SP in symptomatic 6-59 month children with uncomplicated malaria and in asymptomatic 2-10 month old infants. METHODOLOGY AND PRINCIPAL FINDINGS: An open label single arm (SP) standard 28 day in vivo WHO antimalarial efficacy protocol was used in 6 to 59 months old symptomatic children and a modified protocol used in 2 to 10 months old asymptomatic infants. Enrolment was stopped early (87 in the symptomatic and 25 in the asymptomatic studies) due to the high failure rate. Molecular markers were examined for recrudescence, re-infection and markers of drug resistance and a review of literature of studies looking for the 581G dhps mutation was carried out. In symptomatic children PCR-corrected early treatment failure was 38.8% (95% CI 26.8-50.8) and total failures by day 28 were 82.2% (95% CI 72.5-92.0). There was no significant difference in treatment failures between asymptomatic and symptomatic children. 96% of samples carried parasites with mutations at codons 51, 59 and 108 in the dhfr gene and 63% carried a double mutation at codons 437 and 540. 55% carried a third mutation with the addition of a mutation at codon 581 in the dhps gene. This triple: triple haplotype maybe associated with earlier treatment failure. CONCLUSION: In northern Tanzania SP is a failed drug for treatment and its utility for prophylaxis is doubtful. The study found a new combination of parasite mutations that maybe associated with increased and earlier failure. TRIAL REGISTRATION: ClinicalTrials.gov NCT00361114

Rebound Discharge in Deep Cerebellar Nuclear Neurons In Vitro

Neurons of the deep cerebellar nuclei (DCN) play a critical role in defining the output of cerebellum in the course of encoding Purkinje cell inhibitory inputs. The earliest work performed with in vitro preparations established that DCN cells have the capacity to translate membrane hyperpolarizations into a rebound increase in firing frequency. The primary means of distinguishing between DCN neurons has been according to cell size and transmitter phenotype, but in some cases, differences in the firing properties of DCN cells maintained in vitro have been reported. In particular, it was shown that large diameter cells in the rat DCN exhibit two phenotypes of rebound discharge in vitro that may eventually help define their functional roles in cerebellar output. A transient burst and weak burst phenotype can be distinguished based on the frequency and pattern of rebound discharge immediately following a hyperpolarizing stimulus. Work to date indicates that the difference in excitability arises from at least the degree of activation of T-type Ca2+ current during the immediate phase of rebound firing and Ca2+-dependent K+ channels that underlie afterhyperpolarizations. Both phenotypes can be detected following stimulation of Purkinje cell inhibitory inputs under conditions that preserve resting membrane potential and natural ionic gradients. In this paper, we review the evidence supporting the existence of different rebound phenotypes in DCN cells and the ion channel expression patterns that underlie their generation